Salutary Effect of Commelina benghalensis (Linn.) Aerial Parts on Streptozotocin Induced Diabetes Linked Complications in Rat: Effective Extract Selection Study
Shibani Das, Dibya Pal, Sajani Singharoy, Pampa Lohar, Sukriti Hazra, Debidas Ghosh
The experiment was designed to identify the most effective extract of Commelina benghalensis Linn. aerial parts for the rectification of carbohydrate metabolic disorder, oxidative stress and hyperlipidemia in diabetic rats, developed with a single intramuscular injection of streptozotocin (4 mg/0.1 M citrate
buffer/0.1 kg of body weight). Diabetic rats were treated with 0.02 g of hydro-methanol (60:40) or hydro- ethanol (60:40) or aqueous extract orally per 0.1 kg body weight in 0.5 mL distilled water for 28 days and sacrificed on the 29th day. Glycemic sensor levels, carbohydrate metabolizing enzyme activities, lipid profile,
oxidative stress, toxicity markers, and pancreatic histological changes were assessed using standard protocols.
Treatment with the mentioned extracts of C. benghalensis Linn significantly (p <0.05) improved body weight, fasting blood glucose, serum insulin, lipid profile, and carbohydrate metabolic enzyme kinetics in the liver, kidney, and skeletal muscle in treated groups compared to untreated diabetic control group. Additionally,
treatment of said extracts of C. benghalensis Linn significantly restored (p <0.05) the levels of oxidative stress sensors and pancreatic histology as untreated control group. Among the extracts, the hydro-ethanolic extract showed the highest efficacy for rectifying glycemic status, lipid profile, and oxidative stress condition
for developing a safe, affordable, and multi-targeted antidiabetic herbal drug.